A Tumor Bank, A Tumor Bank is sometimes also referred to as a Tissue Bank, since normal tissues for research are also often collected. However, this function is distinct from a Tissue Bank which collects and harvests human cadaver tissue for medical research and education, and banks which store Biomedical tissue for organ transplantation.
Most tumor banks collect their tumor samples from discarded tissues not needed for pathologic diagnosis, after patients undergo surgery to remove the tumor. The tissue is often snap frozen in liquid nitrogen but may also be preserved in special fixative such as RNAlater (which preserves RNA), or formalin which preserved tissue architecture.
Many Cancer Centers in the U.S. have a Tumor Bank to supply biomedical scientists with actual patient samples of cancer and associated adjacent normal tissue. This process is currently a high priority to support more Translational Research.
All institutional banks preserve tissue for Research and not for the patient. At the time of surgery, patients are connected to donate their tissue for research, and so the patient looses control over their tissue after the surgery.
Personalized Medicine is changing all that, and since the tissue can not be used for treating the patient (Immunotherapy:vaccines, or TIL) or or diagnostics (cheese sensitivity, or Gen seq) patients are looking for private tumor banks to preserve their tumors.
- Hidalgo DO, Entrena NR (2004). "Tumor Banks for genomic and proteomic research". Clinical and Translational Oncology 6: 381–390.
- Isabelle M, Teodorovic I, Morente MM et al. (December 2006). "TuBaFrost 5: multifunctional central database application for a European tumor bank". Eur. J. Cancer 42 (18): 3103–9. PMID 17029787. doi:10.1016/j.ejca.2006.04.032.