Open Access Articles- Top Results for Type II cytokine receptor

Type II cytokine receptor

Type II cytokine receptors are transmembrane proteins that are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors.


Typically type II cytokine receptors are heterodimers or multimers with a high and a low affinity component. Currently no complete structure of the extracellular domains of a type II cytokine receptor is available. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family.


Type II cytokine receptors include those that bind type I and type II interferons, and those that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22).[1][2]

Interferon receptors

The interferon receptor is a molecule displayed on the surface of cells which allows them to interact with the anti-viral substance interferon. The receptor is genetically coded for by number of different genes, as there are a few distinct types of interferon. Interferon receptor deficiency is a condition showing some amenability to genetic therapy.[3]

Interleukin receptors


  1. ^ Dumoutier L, Lejeune D, Hor S, Fickenscher H, Renauld JC (2003). "Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3". Biochem. J. 370 (Pt 2): 391–6. PMC 1223207. PMID 12521379. doi:10.1042/BJ20021935. 
  2. ^ Xu W; Presnell SR; Parrish-Novak J et al. (2001). "A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9511–6. PMC 55483. PMID 11481447. doi:10.1073/pnas.171303198. 
  3. ^ Reuter U, Roesler J, Thiede C, Schulz A, Classen CF, Oelschlagel U, Debatin KM, Friedrich W (2002). "Correction of complete interferon-gamma receptor 1 deficiency by bone marrow transplantation". Blood 100 (12): 4234–5. PMID 12393576. doi:10.1182/blood-2002-02-0433. 

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