Urethra is tube at center.
|Classification and external resources|
|Patient UK||Urethral stricture|
Signs and symptoms
The hallmark sign of urethral stricture is a weak urinary stream. Other symptoms include:
- Splaying of the urinary stream
- Urinary frequency
- Urinary urgency
- Straining to urinate
- Pain during urination
- Urinary tract infection
- Inability to complete empty the bladder.
Some patients with severe urethral strictures are completely unable to urinate. This is referred to as acute urinary retention, and is a medical emergency. Hydronephrosis and renal failure may also occur.
- Urinary retention
- Bladder dysfunction
- Urethral diverticulum
- Periurethral abscess
- Fournier's gangrene
- Urethral fistula
- Bilateral hydronephrosis
- Urinary infections
- Urinary calculus
Urethral strictures most commonly result from injury, urethral instrumentation, infection, non-infectious inflammatory conditions of the urethra, and after prior hypospadias surgery. Less common causes include congenital urethral strictures and those resulting from malignancy.
Urethral strictures after blunt trauma can generally be divided into two sub-types.
- Pelvic fracture-associated urethral disruption occurs in as many as 15% of severe pelvic fractures. These injuries are typically managed with suprapubic tube placement and delayed urethroplasty 3 months later. Early endoscopic realignment may be used in select cases instead of a suprapubic tube, but these patients should be monitored closely as vast majority of them will require urethroplasty
- Blunt trauma to the perineum compresses the bulbar urethra against the pubic symphysis, causing a "crush" injury. These patients are typically treated with suprapubic tube and delayed urethroplasty.
Other specific causes of urethral stricture include
- Instrumentation (e.g., after transurethral resection of prostate, transurethral resection of bladder tumor, or endoscopic kidney surgery)
- Infection (typically with Gonorrhea)
- Lichen sclerosis
- Surgery to address hypospadias can result in a delayed urethral stricture, even decades after the original surgery
Dilation and other endoscopic approaches
Urethral dilation and other endoscopic approaches such as direct vision internal urethrotomy (DVIU, laser urethrotomy, and self intermittent dilation are the most commonly used treatments for urethral stricture. However, these approaches are associated with low success rates and may worsen the stricture, making future attempts to surgically repair the urethra more difficult.
Urethroplasty refers to any open reconstruction of the urethra.
In the posterior urethra, anastomotic urethroplasty (with or without preservation of bulbar arteries) is typically performed after removing scar tissue.
In the bulbar urethra, the most common types of urethroplasty are anastomotic (with or without preservation of corpus spongiosum and bulbar arteries) and substitution with buccal mucosa graft, full-thickness skin graft, or split thickness skin graft. These are nearly always done in a single setting (or stage).
In the penile urethra, anastomotic urethroplasties are rare because they can lead to chordee (penile curvature due to a shortened urethra). Instead, most penile urethroplasties are subsitution procedures utilizing buccal mucosa graft, full-thickness skin graft, or split thickness skin graft. These can be done in one or more setting, depending on stricture location, severity, etiology and patient/surgeon preference.
A permanent urethral stent  was approved for use in men with bulbar urethral strictures in 1996, but was recently removed from the market.
A temporary thermoexpandable urethral stent (Memotherm) is available in Europe, but is not currently approved for use in the United States.
When in acute urinary retention, treatment of the urethral stricture or diversion is an emergency. Options include:
- Urethral dilatation and catheter placement. This can be performed in the Emergency Department, a practitioner's office or an operating room. The advantage of this approach is that the urethra may remain patent for a period of time after the dilation, though long-term success rates are low.
- Insertion of a suprapubic catheter with catheter drainage system. This procedure is performed in an Operating Room, Emergency Department or practitioner's office. The advantage of this approach is that it does not disrupt the scar and interfere with future definitive surgery.
Following urethroplasty, patients should be monitored for a minimum of 1 year, since the vast majority of recurrences occur within 1 year.
Because of the high rate of recurrence following dilation and other endoscopic approaches, the provider must maintain a high index of suspicion for recurrence when the patient presents with obstructive voiding symptoms or urinary tract infection.
Bioengineered urethral tissue research
The Wake Forest Institute of Regenerative Medicine has pioneered the first bioengineered human urethra, and in 2006 implanted urethral tissue grown on bioabsorbable scaffolding (approximating the size and shape of the affected areas) in five young (human) males who suffered from congenital defects, physical trauma, or an unspecified disorder necessitating urethral reconstruction. As of March, 2011, all five recipients report the transplants have functioned well.
- "Urethral stricture: What causes it? - MayoClinic.com". Archived from the original on 2007-11-26. Retrieved 2007-12-13.
- Urolume Endoprosthesis
- MacDonald MF, Al-Qudah HS, Santucci RA (October 2005). "Minimal impact urethroplasty allows same-day surgery in most patients". Urology 66 (4): 850–3. PMID 16230151. doi:10.1016/j.urology.2005.04.057.
- Al-Qudah HS, Cavalcanti AG, Santucci RA (2005). "Early catheter removal after anterior anastomotic (3 days) and ventral buccal mucosal onlay (7 days) urethroplasty". International Braz J Urol 31 (5): 459–63; discussion 464. PMID 16255792. doi:10.1590/S1677-55382005000500007.
- Santucci RA, McAninch JW, Mario LA et al. (July 2004). "Urethroplasty in patients older than 65 years: indications, results, outcomes and suggested treatment modifications". J Urol. 172 (1): 201–3. PMID 15201773. doi:10.1097/01.ju.0000128810.86535.be.
- Kizer WS, Armenakas NA, Brandes SB, Cavalcanti AG, Santucci RA, Morey AF (April 2007). "Simplified reconstruction of posterior urethral disruption defects: limited role of supracrural rerouting". J Urol. 177 (4): 1378–81; discussion 1381–2. PMID 17382736. doi:10.1016/j.juro.2006.11.036.
- Al-Qudah HS, Santucci RA (2005). "Extended complications of urethroplasty". Int Braz J Urol. 31 (4): 315–23; discussion 324–5. PMID 16137399. doi:10.1590/s1677-55382005000400004.
- Santucci RA, Mario LA, McAninch JW (April 2002). "Anastomotic urethroplasty for bulbar urethral stricture: analysis of 168 patients". J Urol. 167 (4): 1715–9. PMID 11912394. doi:10.1016/S0022-5347(05)65184-1.
- Essentials of Surgery 4th Edition 2007 by Professor Muhammad Shamim
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