Adverts

Open Access Articles- Top Results for Uridine

Uridine

Template:Chembox UNII
Uridine
Skeletal formula of uridine
Ball-and-stick model of the uridine molecule
colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other
This page is a soft redirect. Names

#REDIRECTmw:Help:Magic words#Other
This page is a soft redirect.-

IUPAC name
1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Other names
uridine
colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other
This page is a soft redirect. Identifiers#REDIRECTmw:Help:Magic words#Other
This page is a soft redirect.-



58-96-8 7pxY
ChEMBL ChEMBL100259 7pxN
ChemSpider 5807 7pxN
DrugBank DB02745 7pxY
Jmol-3D images Image
MeSH Uridine
colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other
This page is a soft redirect. Properties

#REDIRECTmw:Help:Magic words#Other
This page is a soft redirect.-

C9H12N2O6
Molar mass Lua error in Module:Math at line 495: attempt to index field 'ParserFunctions' (a nil value). g·mol−1
Appearance solid
Density .99308g/cm3
Melting point Script error: No such module "convert". 
log P -1.98
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 14pxN verify (what is10pxY/10pxN?)
Infobox references

Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a β-N1-glycosidic bond.

It is one of the five standard nucleosides which make up nucleic acids, the others being adenosine, thymidine, cytidine and guanosine. The five nucleosides are commonly abbreviated to their one letter codes U, A, T, C and G respectively. However, thymidine is more commonly written as 'dT' ('d' represents 'deoxy') as it contains a 2'-deoxyribofuranose moiety rather than the ribofuranose ring found in uridine. This is because thymidine is found in deoxyribonucleic acid (DNA) and not ribonucleic acid (RNA). Conversely, uridine is found in RNA and not DNA. The remaining three nucleosides may be found in both RNA and DNA. In RNA, they would be represented as A, C and G whereas in DNA they would represented as dA, dC and dG.

Dietary sources of uridine

Some foods that contain uridine in the form of RNA are listed below. However virtually none of the uridine in this form is bioavailable, since - as shown by Handschumacher's Laboratory at Yale Medical School in 1981 (Gasser, et al., Science, 1981, 213:777) - it is destroyed in the liver and gastrointestinal tract, and no food, when consumed, has ever been reliably shown to elevate blood uridine levels. In infants consuming mothers'milk or commercial infant formulas, uridine is present as its monophosphate, UMP,[citation needed] and this source of uridine is indeed bioavailable[1] and enters the blood.[citation needed]

  • Sugarcane extract[2]
  • Tomatoes (0.5 to 1.0 g uridine per kilogram dry weight)[3]
  • Brewer’s yeast (1.7% uridine by dry weight)[4][5]
  • Beer[6]
  • Broccoli[4]
  • Offal (liver, pancreas, etc.)[4]

Consumption of RNA-rich foods may lead to high levels of purines (adenosine and guanosine) in blood. High levels of purines are known to increase uric acid production and may aggravate or lead to conditions such as gout. Moderate consumption of yeast, about 5 grams per day, should provide adequate uridine for improved health with minimal side effects.[citation needed]

Note: It has been suggested that the RNA content of yeast products should be chemically reduced if these products are to be consumed in high amounts (50 grams or more per day) as a source of protein. However, such processing is expensive and, as of 2008, commonly available brewer's yeast products were not RNA-reduced.[citation needed]

Harvard researchers report that supplementation in rats with a combination of uridine and EPA/DHA omega-3 fatty acids has antidepressant activity.[7]

In the glycolysis pathway

Uridine plays a role in the glycolysis pathway of galactose.[8] There is no catabolic process to metabolize galactose. Therefore, galactose is converted to glucose and metabolized in the common glucose pathway. Once the incoming galactose has been converted into galactose 1-phosphate (Gal-1-P), it is involved in a reaction with UDP-glucose, a glucose molecule bonded to uridine diphosphate (UDP). This process is catalyzed by the enzyme galactose-1-phosphate uridyl transferase and transfers the UDP to the galactose molecule. The end result is UDP-galactose and glucose-1-phosphate. This process is continued to allow the proper glycolysis of galactose.

References

  1. Carver, J.D. (2003). "Advances in nutritional modifications of infant formulas". The American Journal of Clinical Nutrition 77 (6): 1550S–1554S. 
  2. Thebody.com
  3. Aseanfood.info
  4. 4.0 4.1 4.2 Jonas DA, Elmadfa I, Engel KH, Heller KJ, Kozianowski G, König A, Müller D, Narbonne JF, Wackernagel W, Kleiner J (2001). "Safety considerations of DNA in food". Ann Nutr Metab 45 (6): 235–54. PMID 11786646. doi:10.1159/000046734. 
  5. Storck, R., 1965. Nucleotide Composition of Nucleic Acids of Fungi I. Ribonucleic Acids. J Bacteriol 90, 1260–1264.
  6. Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Ka T, Fukuchi M, Hada T (October 2002). "Effect of beer on the plasma concentrations of uridine and purine bases". Metab Clin Exp 51 (10): 1317–23. PMID 12370853. doi:10.1053/meta.2002.34041. 
  7. Carlezon WA, Mague SD, Parow AM, Stoll AL, Cohen BM, Renshaw PF (February 2005). "Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats". Biol Psychiatry 57 (4): 343–50. PMID 15705349. doi:10.1016/j.biopsych.2004.11.038. 
  8. Stryer, Berg and Tymoczko (2002). "Section 16.1 Glycolysis Is an Energy-Conversion Pathway in Many Organisms". Biochemistry (5th ed.). New York: W H Freeman.