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Open Access Articles- Top Results for Valofane

Valofane

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Valofane
200px
Systematic (IUPAC) name
3-allyl-N-(aminocarbonyl)-5-methyl-2-oxotetrahydrofuran-3-carboxamide
Clinical data
Identifiers
3258-51-3 7pxN
None
PubChem CID 71122
ChemSpider 64272 7pxY
UNII X71N6E5IPO 7pxY
ChEMBL CHEMBL2104479 7pxN
Synonyms N-carbamoyl-5-methyl-2-oxo-3-prop-2-enyloxolane-3-carboxamide
Chemical data
Formula C10H14N2O4
226.229 g/mol
 14pxN (what is this?)  (verify)

Valofane is a sedative drug structurally related to the barbiturates[1] and similar drugs such as primidone. It is metabolised once inside the body to form the barbiturate proxibarbal and is thus a prodrug.[2]

References

  1. Traversa U, Puppini P, Jacquot C, Vertua R. Effect of an atypical barbiturate, the 2-allophanyl-2-allyl-4-valerolactone (valofan), on exploratory behaviour and brain serotonin concentrations in mice. Journal de Pharmacologie. 1985 Jul-Sep;16(3):279-90.
  2. Lambrey B, Compagnon PL, Jacquot C. Pharmacokinetics of 14C-2-allophanyl-2-allyl -gamma-valero-lactone: a prodrug of proxibarbal in rats. European Journal of Drug Metabolism and Pharmacokinetics. 1981;6(3):161-9.



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