Adverts

Open Access Articles- Top Results for Vasoactive intestinal peptide receptor

Vasoactive intestinal peptide receptor

vasoactive intestinal peptide receptor 1
Identifiers
Symbol VIPR1
Alt. symbols RDC1, HVR1, VAPC1
Entrez 7433
HUGO 12694
OMIM 192321
RefSeq NM_004624
UniProt P32241
Other data
Locus Chr. 3 p22
vasoactive intestinal peptide receptor 2
Identifiers
Symbol VIPR2
Alt. symbols VPAC2
Entrez 7434
HUGO 12695
OMIM 601970
RefSeq NM_003382
UniProt P41587
Other data
Locus Chr. 7 q36.3
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Identifiers
Symbol ADCYAP1R1
Alt. symbols PACAPR
Entrez 117
HUGO 242
OMIM 102981
RefSeq NM_001118
UniProt P41586
Other data
Locus Chr. 7 p14

There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC1 and VPAC2.[1][2] These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G protein-coupled receptor family.

VPAC1 is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes.

VPAC2 is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach.

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors are activated by the endogenous peptides VIP, PACAP-38, PACAP-27, peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM) and peptide histidine valine (PHV). “PACAP type II receptors” (VPAC1 and VPAC2 receptors) display comparable affinity for PACAP and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent than VIP as agonists of most isoforms of the PAC1 receptor.[3]

References

  1. ^ Laburthe M, Couvineau A, Marie JC (2002). "VPAC receptors for VIP and PACAP". Recept. Channels 8 (3-4): 137–53. PMID 12529932. doi:10.1080/10606820213680. 
  2. ^ Laburthe M, Couvineau A (2002). "Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP". Regul. Pept. 108 (2-3): 165–73. PMID 12220741. doi:10.1016/S0167-0115(02)00099-X. 
  3. ^ "VIP and PACAP receptors". IUPHAR Guide to Pharmacology. The British Pharmacological Society (BPS) and the International Union of Basic and Clinical Pharmacology (IUPHAR). 

External links

Lua error in package.lua at line 80: module 'Module:Buffer' not found.