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Vesicular glutamate transporter 1

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsSLC17A7 ; BNPI; VGLUT1
External IDsOMIM605208 HomoloGene113454 IUPHAR: 1007 GeneCards: SLC17A7 Gene
RNA expression pattern
File:PBB GE SLC17A7 204230 s at tn.png
File:PBB GE SLC17A7 204229 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez5703072961
EnsemblENSG00000104888ENSMUSG00000070570
UniProtQ9P2U7Q3TXX4
RefSeq (mRNA)NM_020309NM_182993
RefSeq (protein)NP_064705NP_892038
Location (UCSC)Chr 19:
49.93 – 49.95 Mb
Chr 7:
45.16 – 45.18 Mb
PubMed search[1][2]

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.[1][2][3]

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.[3]

See also

References

  1. ^ Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem 66 (6): 2227–38. PMID 8632143. doi:10.1046/j.1471-4159.1996.66062227.x. 
  2. ^ Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem 74 (6): 2622–5. PMID 10820226. 
  3. ^ a b "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7". 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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