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Open Access Articles- Top Results for WAY-161503

WAY-161503

WAY-161503
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IUPAC name
(R)-8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one
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276694-95-2 7pxY
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C11H11Cl2N3O
Molar mass Lua error in Module:Math at line 495: attempt to index field 'ParserFunctions' (a nil value). g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

WAY-161503 is a full agonist at the serotonin 5-HT2B and 5-HT2C receptors. Administration of WAY-161503 decreased food intake in rats, an effect mediated by its action on the 5-HT2C receptors. In addition, there was no development of tolerance with up to 15 days of treatment. However, clinical utility of WAY-161,503 may be limited as activation of the 5-HT2B receptor has been linked to pulmonary hypertension and cardiac valve problems.[1]

References

  1. ^ Rosenzweig-Lipson, Sharon (February 2006). "Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503". Brain Research. 1073-1074: 240–251. PMID 16430874. doi:10.1016/j.brainres.2005.12.052.