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Wee1-like protein kinase

See also: Wee1
SymbolsWEE1 ; WEE1A; WEE1hu
External IDsOMIM193525 MGI103075 HomoloGene31152 IUPHAR: 2278 ChEMBL: 5491 GeneCards: WEE1 Gene
EC number2.7.10.2
RefSeq (mRNA)NM_001143976NM_009516
RefSeq (protein)NP_001137448NP_033542
Location (UCSC)Chr 11:
9.6 – 9.62 Mb
Chr 7:
110.12 – 110.14 Mb
PubMed search[1][2]

WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.[1]


This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.[2]


Wee1-like protein kinase has been shown to interact with YWHAB[3] and PIN1.[4]


  1. ^ Igarashi M, Nagata A, Jinno S, Suto K, Okayama H (September 1991). "Wee1(+)-like gene in human cells". Nature 353 (6339): 80–3. PMID 1840647. doi:10.1038/353080a0. 
  2. ^ "Entrez Gene: WEE1 WEE1 homolog (S. pombe)". 
  3. ^ Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. (UNITED STATES) 11 (4): 211–9. ISSN 1044-9523. PMID 10775038. 
  4. ^ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (March 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. (UNITED STATES) 12 (5): 706–20. ISSN 0890-9369. PMC 316589. PMID 9499405. doi:10.1101/gad.12.5.706. 

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