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Open Access Articles- Top Results for Wogonin

Wogonin

Wogonin[1]
Skeletal formula
Ball-and-stick model
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IUPAC name
5,7-Dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one
Other names
Vogonin
Norwogonin 8-methyl ether
5,7-dihydroxy-8-methoxyflavone
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632-85-9 7pxY
ChEBI CHEBI:10043 7pxN
ChEMBL ChEMBL16171 7pxN
ChemSpider 4445020 7pxN
Jmol-3D images Image
KEGG C10197 7pxN
PubChem Template:Chembox PubChem/format
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C16H12O5
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Wogonin is an O-methylated flavone, a flavonoid-like chemical compound which was found in Scutellaria baicalensis.[2] The glycosides of wogonin are known as wogonosides. For example, oroxindin is a wogonin glucuronide isolated from Oroxylum indicum.[3] It is one of the active ingredients of Sho-Saiko-To, a Japanese herbal supplement.

Wogonin has been found in one study to have anxiolytic properties in mice at doses of 7.5 to 30 mg/kg, without exhibiting the sedative and muscle-relaxing properties of benzodiazepines.[2] Preliminary in vitro studies have shown pharmacological effects that indicate wogonin may have anti-tumor properties.[4][5] Wogonin has also been found to possess anticonvulsant effects.[6] It acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.[2][6]

References

  1. ^ Wogonin at chemblink.com
  2. ^ a b c Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R et al. (2002). "Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi". Biochem. Pharmacol. 64 (9): 1415–24. PMID 12392823. doi:10.1016/s0006-2952(02)01347-3. 
  3. ^ Ramachandran Nair AG; Joshi BS. "Oroxindin—A new flavone glucuronide from Oroxylum indicum". doi:10.1007/BF02844710. 
  4. ^ Lin CC, Kuo CL, Lee MH, Lai KC, Lin JP, Yang JS, Yu CS, Lu CC, Chiang JH, Chueh FS, Chung JG (2011). "Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways". Int J Oncol 39 (1): 217–224. PMID 21573491. doi:10.3892/ijo.2011.1027. 
  5. ^ Gao J, Morgan WA, Sanchez-Medina A, Corcoran O (2011). "The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells". Toxicol Appl Pharmacol 254 (3): 221–8. PMID 21457722. doi:10.1016/j.taap.2011.03.016. 
  6. ^ a b Park HG, Yoon SY, Choi JY, Lee GS, Choi JH, Shin CY et al. (2007). "Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis". Eur. J. Pharmacol. 574 (2-3): 112–9. PMID 17692312. doi:10.1016/j.ejphar.2007.07.011. 



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