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Open Access Articles- Top Results for XCR1

XCR1

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Identifiers
SymbolsXCR1 ; CCXCR1; GPR5
External IDsOMIM600552 MGI1346338 HomoloGene21095 IUPHAR: 75 ChEMBL: 4339 GeneCards: XCR1 Gene
RNA expression pattern
File:PBB GE XCR1 221468 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez282923832
EnsemblENSG00000173578ENSMUSG00000060509
UniProtP46094Q9R0M1
RefSeq (mRNA)NM_001024644NM_011798
RefSeq (protein)NP_001019815NP_035928
Location (UCSC)Chr 3:
46.06 – 46.07 Mb
Chr 9:
123.85 – 123.86 Mb
PubMed search[1][2]

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]

References

External links

  • "Chemokine Receptors: XCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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