Open Access Articles- Top Results for XCR1


SymbolsXCR1 ; CCXCR1; GPR5
External IDsOMIM600552 MGI1346338 HomoloGene21095 IUPHAR: 75 ChEMBL: 4339 GeneCards: XCR1 Gene
RNA expression pattern
File:PBB GE XCR1 221468 at tn.png
More reference expression data
RefSeq (mRNA)NM_001024644NM_011798
RefSeq (protein)NP_001019815NP_035928
Location (UCSC)Chr 3:
46.06 – 46.07 Mb
Chr 9:
123.85 – 123.86 Mb
PubMed search[1][2]

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]


External links

  • "Chemokine Receptors: XCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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