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Open Access Articles- Top Results for ZM-241,385

ZM-241,385

ZM-241,385
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IUPAC name
4-(2-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol
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139180-30-6 7pxY
ChEMBL ChEMBL1628689 7pxN
ChemSpider 153646 7pxN
IUPHAR ligand 405
Jmol-3D images Image
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C16H15N7O2
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Infobox references

ZM-241,385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.[1]

In animal models, ZM-241,385 has been shown to protect against beta amyloid neurotoxicity and therefore may be useful as a treatment for Alzheimer's disease.[2] ZM-241,385 has also been shown to enhance L-DOPA derived dopamine release and therefore may be useful in the treatment of Parkinson's disease.[3]

References

  1. Palmer TM, Poucher SM, Jacobson KA, Stiles GL (December 1995). "125I-4-(2-(7-amino-2-(2-furyl)(1,2,4)triazolo(2,3-a)(1,3,5) triazin-5-yl-amino)ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptor". Molecular Pharmacology 48 (6): 970–4. PMC 3479638. PMID 8848012. 
  2. Dall'Igna OP, Porciúncula LO, Souza DO, Cunha RA, Lara DR, Dall'lgna OP (April 2003). "Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity". British Journal of Pharmacology 138 (7): 1207–9. PMC 1573785. PMID 12711619. doi:10.1038/sj.bjp.0705185. 
  3. Gołembiowska K, Dziubina A (September 2004). "Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats". Neuropharmacology 47 (3): 414–26. PMID 15275831. doi:10.1016/j.neuropharm.2004.04.018. 

External links

ZM 241385 at the US National Library of Medicine Medical Subject Headings (MeSH)



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