Open Access Articles- Top Results for Zipeprol


Systematic (IUPAC) name
1-methoxy- 3-[4-(2-methoxy- 2-phenylethyl)piperazin- 1-yl]- 1-phenylpropan- 2-ol
Clinical data
AHFS/ International Drug Names
34758-83-3 7pxN
PubChem CID 36910
ChemSpider 33868 7pxY
UNII G5MUV8139H 7pxY
KEGG D07390 7pxY
Chemical data
Formula C23H32N2O3
384.512 g/mol
 14pxN (what is this?)  (verify)

Zipeprol is a centrally acting cough suppressant developed in France in the 1970s.[1] It is not an morphinan derivative (in contrast to codeine and dextromethorphan). Zipeprol acts as a local anaesthetic and has mucolytic, antihistamine and anticholinergic properties.[2]It is sold with several brand names such as Zinolta and Respilene. It is not available in the United States or Canada and has been discontinued in Europe. It is still available in some countries in Asia and South America.

Zipeprol has been misused in Korea, mainly for the hallucinations it produces. Such use has become an issue due to the seizures and various neurological side effects it causes at high dosages.[3]


  1. ^ Patent US 3718650, Mauvernay,RY, "New Derivatives of Substituted Piperazines", issued 1973-02-27 
  2. ^ Rispat, G.; Burgi, H.; Cosnier, D.; Duchêne-Marullaz, P.; Streichenberger, G. (1976). "General pharmacological properties of a new non-opiate antitussive: Zipeprol (3024 CERM). I. Action on respiratory function and acute toxicity". Arzneimittel-Forschung 26 (4): 523–530. PMID 8057.  edit
  3. ^ Chung, H.; Park, M.; Hahn, E.; Choi, H.; Choi, H.; Lim, M. (2004). "Recent Trends of Drug Abuse and Drug-Associated Deaths in Korea". Annals of the New York Academy of Sciences 1025: 458–464. PMID 15542749. doi:10.1196/annals.1316.056.  edit

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